| Strain-specific Detection of Bacillus Anthracis using Multiple-locus Variable-number Tandem Repeat Analysis |
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Kyoung-Hwa Jung, Sang-Hoon Kim, Seong-Joo Kim, Ji-Cheon Kim, Young-Gyu Chai |
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| Multiple-locus Variable-number Tandem Repeat 분석을 사용한 Bacillus Anthracis 균주간 특이성 규명 |
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정경화, 김상훈, 김성주, 김지천, 채영규 |
1한양대학교
2국방과학연구소 |
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| Abstract |
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Bacillus anthracis(Ba) is a Gram-positive spore-forming bacterium that causes the disease anthrax. The feature of Ba is the presence of two large virulence plasmids, pXO1 and pXO2. Molecular genotyping of Ba has been difficult to the lack of polymorphic DNA marker. Ba isolated from Korea has been genotyped using various nucleotide analysis methods, such as 16s rDNA sequencing and multiple-locus variable-number tandem repeat (MLVA) analysis. We identified genotypes that represent a genetic lineage in the B1 cluster. This study emphasized the need to perform molecular genotyping when attempting to verify a strain-specific Ba. |
| Key Words:
Bacillus Anthracis, Isolation, Verification, Molecular Genotyping |
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