| Biomarkers for Combat-Related Stress and Fatigue-Mitigating Drugs Discovery |
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Hyojin Koo, Chang Yul Kim, Yeonkyung Kim, So Jung Sin, Kicheol Cheon, Dongsoo Kim |
1Department of Basic Science, Air Force Academy
2Department of Occupational Health, Catholic University of Daegu
3The 5th Research and Development Institute, Agency for Defense Development |
| 전투 스트레스 및 피로 완화 약물 탐색을 위한 생체지표 |
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구효진, 김창열, 김연경, 신소정, 천기철, 김동수 |
1공군사관학교 기초과학과
2대구가톨릭대학교 산업보건학과
3국방과학연구소 제5기술연구본부 |
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| Abstract |
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Psychological stress and physical fatigue, such as anxiety, fear, sleep disturbance, etc., caused by exposure to the war, can lead to post-traumatic stress syndrome(PTSD) or war syndrome. The military has also prepared for drug use to minimize war syndrome and preserve combat strength. However, efforts to prevent war syndrome are still lacking. This study was conducted to identify biomarkers that can track psychophysiological changes. Psychophysiological changes associated with PTSD can be divided into four main categories. The four categories are behavioral changes, changes in brain cognition, neuroimmunological changes, and changes in innate immunity. This study suggest that biomarker profile can be made by the distance moved and the anxiety-like behavior in the open field for behavior category, brain BDNF levels in the brain cognition category, serum corticosterone in the neuroimmunology category, and inflammatory cytokine levels in the innate immunity category. |
| Key Words:
Stress, Fatigue, Biomarker, Combat-Related PTSD, Animal Model, Drug |
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