| Investigation of the Pharmacological Mechanisms and the R&D of Medical Countermeasures Against Nerve Agent Poisoning |
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Young Cho |
| 신경작용제 해독제의 약리기전 및 연구개발 |
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조영 |
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국방과학연구소 |
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| Abstract |
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Nerve agents are irreversible inhibitors of the cholinesterase enzyme. Exposure causes a progression of toxic signs, including hypersecretions, fasciculations, tremor, convulsions, respiratory distress, epileptiform seizures, brain injuries and death. A combined regimen of prophylaxis and therapy is the most effective medical countermeasure for dealing with the threat of nerve agent poisoning to military personnel. In this paper, the author investigated the updated technologies regarding various pre- and post-treatment drugs for nerve agents detoxification which are under development in several countries including Korea. Some characteristics of active ingredients in the formulations of drugs, their action mechanisms, and effectiveness were analyzed. Additionally, part of experimental data on the transdermal patch studied in ADD using beagle dogs was introduced. |
| Key Words:
Nerve Agent, Antidote, Poisoning, Prophylactic Patch |
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