Measurement and Analysis of Rodent Biological Signals using Telemetry System

Kim, Chang-Hwan; Hur, Gyeong-Haeng

doi:2011.14.6.1159

J. KIMS Technol > Volume 14(6); 2011 > Article

Journal of the Korea Institute of Military Science and Technology 2011;14(6):1159-1165.
DOI: https://doi.org/10.9766/KIMST.2011.14.6.1159

Measurement and Analysis of Rodent Biological Signals using Telemetry System

Chang-Hwan Kim, Gyeong-Haeng Hur

원격측정장치를 이용한 설치류의 생체신호 측정 및 분석

김창환, 허경행

국방과학연구소

Abstract

Telemetry techniques of rats have been used for assessing safety pharmacology of drugs and chemicals. Biological signals including blood pressure and heart rate measured under anesthesia were significantly different from those obtained under normal conditions. The stress of restraint in awake animals can also affect the accuracy of physiological evaluation. This paper details the surgery required to allow key cardiovascular parameters to be determined. The telemetric measurement of cardiovascular parameters such as blood pressure, heart rate, electrocardiograph(ECG) established. We carried out the continuous monitoring of cardiovascular parameters using the telemetry system in F344 rats. During the measurement, no significant changes were observed in the heart rate and blood pressure. ECG signals and body temperature were also constant during the measurement of biological signals. With the results of this study, we conclude that this telemetry system can be applied usefully for the assesment of biological parameters in the rats.

Key Words: Telemetry System, Biological Signal, Electrocardiograph, Blood Pressure, Safety Pharmacology